Yes, I have it and use it with Fritz 11/Rybka 3 interface. I like it very much. The only disappointment was the "annotated" games. These are not annotated in the way of the old chess books. They are just references to similar/identical positions in other games and lists of variations.
You should also be able to use it with ChessBase Lite - which is a free program.
Just ordered it and was wondering what the program was like. Don't have the required program for it but apparently the database will work in fritz 11.