Sure. Nf3 stakes some claim in the centre, specifically the e5 square which black will need to support in order to push his e-pawn there. Nf3 also helps support c4 and/or d4.
Nc3 doesn't do much to influence the centre. Black does not have to support the d5 square because the Q is already supporting it. The N on c3 becomes a target of pawn advances and wastes tempi. Nf3 does not have this problem. Also, Nc3 doesn't really support e4 or f4 because playing these moves with the N already on c3 leads to easy equality for black (compare the Vienna: 1.e4, e5 2.Nc3 which is interesting and was feared 100 years ago, but black has found several ways to equalize with a comfortable game.)
1.Nf3 is more flexible and allows white to fight for an advantage.
Hope this helps.
1. Nf3 is the 3. most common opening move. 1. Nc3 is number 8 on the list, and used very rarely, in fact only once for every 73 times 1. Nf3 is played. At the surface these two moves look rather similar. However, while 1. Nf3 is favoring White (56-44), 1. Nc3 is favoring Black (54-46). These numbers are calculated using the date in the Game Explorer.
Can anyone explain why this is so? To me it seems rather stange, that opening with the Knight that defends the King pawn is so much worse than opening with the one that defends the Queen pawn. Can anyone give a good explanation for this odd disparity?
Thanks!