There are numerous openings that are good for white (aka: they don't give up the advantage to black). I think modern play has shown that 1. e4, d4, c4, and Nf3 are all great starters.
I'm not too sure what you mean by "best opening," though. I prefer many lines in the Scotch Game, myself, but there will never be an opening that's so amazing that it automatically wins or anything like the such.
I always wondered, what would be the best opening?