It is hard to answer "generic" questions like that in a forum.
Q : How do you play 1...e5?
A : Carefully?
There are a lot of books and online lectures + articles for learning the ideas behind an opening. Perhaps you've just not found a system you like?
When I first started playing chess, 1...e5 was the only way I know how to respond to 1. e4. After a couple months I stopped play e5 entirely. I felt like it gave white alot of initiative and I hate going into the very symmetrically Italian Game.
Also I found that going on later in the game I would have trouble defending against white's Attack. It seems like by playing this move our at the complete mercy at white. Throughout most of the game White has initiative.
How do you Play e5?