Nf6?
The b3 anti Sicilian

I suppose it is a matter taste. Nothing wrong with Titan's suggestion of the Botvinnk set-up, basically bogging up the dark squares. The thing is though if you use that strategy, some Synder Sicilian players have been know to try a King's gambit type set up by immediately lashing out with f4 at some early stage. Then again, there is nothing wrong with Attja's Nf6 suggestion either re Gurgenidze-Lukin USSR 1979 which accoring to BCO produced an unclear position out of the opening. BCO prefers 2...d6 3.Bb2 Nf6 4.Bb5+ Bd7 5.Bxd7 Qxd7 6.Bxf6 I shalln't repeat the whole line, check out Spassky-Hubner Buenos Aires Ol1978. Mind you good old MOB has presented 2...d6 3.Nf3 Nf6 4.e5!...Like I say, it is just a matter of taste.
How do you play against it?