Move any pieces that control the center and not the side.
What is the best way to open a chess game?

There is no set way to open the game. If you are a beginner then keep it simple till your knowledge grows. just follow some basic guidelines. Get some control in the center, develop your pieces, Keep the king safe.

I find it's best to shake your opponent's hand and offer a pregame greeting. What happens on the board after that usually isn't best by any standard, unless your name happens to be Kramnik, Anand, or Kasparov.

I believe it is better if you're playing white because you have a many choices, but if you play black it's always tricky if your opponent is smarter and fast in development.

The best way to start a chess game is...
- Develop all your pieces! What good is a piece sitting around on the back rank!
- Avoid moving too many pawns, moving the same piece twice, or blocking pieces in (unless you have an exceptional reason for doing so, no "cuz I feel like it" is not an exceptional reason.)
- Get your king to safety!
- Control the center.
- If in doubt, knights before bishops!
- Your queen can be a target for lower value pieces! Don't carelessly bring it out early!
- What move should you play first? Why there are lots of good moves with plenty of merit. However the most principled, easiest to understand (and thus easy to play), and most popular are moving the centermost pawns king 2 spaces forward. Controlling the center! Not blocking in pieces! Getting ready to develop a bishop! Keeping your king safe by making a step towards castling!
I thought the best way to open a chess game was to carefully opn the box and slide everything out so you didn't ruin the styrofoam it was packed in??? I know, bad joke. I think the best way to open is whatever lines play the game you like to play, either positional or tactical, and make sure to develop pices as has been said before instead of quick attacks that lose tempo.

The best way to start a chess game is...
Develop all your pieces! What good is a piece sitting around on the back rank!Avoid moving too many pawns, moving the same piece twice, or blocking pieces in (unless you have an exceptional reason for doing so, no "cuz I feel like it" is not an exceptional reason.)
Get your king to safety! Control the center.
If in doubt, knights before bishops! Your queen can be a target for lower value pieces! Don't carelessly bring it out early! What move should you play first? Why there are lots of good moves with plenty of merit. However the most principled, easiest to understand (and thus easy to play), and most popular are moving the centermost pawns king 2 spaces forward. Controlling the center! Not blocking in pieces! Getting ready to develop a bishop! Keeping your king safe by making a step towards castling!
Nope. According to Silman the best way to open a chess game is to create favorable imbalances. If you just develop your pieces may not fit into a plan.

There are a range of powerful openings, the main thing to do is capture the centre of the board.If you do that in the opening, you will have a huge positional advantage later in the game.

any pawn around the queen is a decent start I think, then I usually try to open up the bishups and get knights in the action too.
Move the pawn two spaces above the king.