This is basically unaswerable question because the term opening is very vague. For example some people might call the Sicilian defence (1. e4 c5) an opening. We might also call the Rossolimo Sicilian (1. e4 c5 2. Nf3 Nc6 3. Bb5) an opening. Obviously the first one will be more common than the latter. In general the earlier the said opening is reached the more common it will be.
Question like what is the most popular first move in GM practice during last 5 years can sensibly be answered by studying a chess database. Question 'what is the most popular opening' cannot unless we first agree on exact definition about what constitutes an opening.
Hello! I would like to know the most common opening played by grandmasters. Please tell me if you know.