As with live chess, I would not give up if you can generate counterplay or have some resources left to try. If no obvious "tricks" are in the position, then I'd simply resign; especially in a daily game where you'd be dragging out a game you both know the result of. I can't comment on the position of an ongoing game, but you'll have to decide if you think you can salvage something despite the point deficit. If you can't, then resign.
Queen Blunder

Thanks mate for feedback, appreciate it, impulsively you feel you need to resign when you loose your main piece, just need to take a beep breath, and see if I can frustrate the opponent into making a mistake, I have a free run with a pawn up the A file ;-) to gain my queen back.

There is a golden rule for resigning which is when you can understand the position is winning and can see how your opponent can convert the position into a win, it's time to resign. Even when you assume you are better than your opponent, you can expect your opponent to find the win if you can find it for them. The exception is like Keto explained when you can find some tricks. In a lost position these are usually called 'cheap shots' or 'cheapos'. Looking for perpetual check or stalemate are prime examples of this.

Here's a game from one of the ongoing Chess.com daily tournaments where I blundered my queen on move 7 and managed to pull out a draw. I'm not sure I'd play this out in a more casual game, but it sure did make the best of a poor situation!

Thanks for the demonstration Paleobotanical, this just demonstrates how important the other pieces are when used precisely with other minor pieces. Thanks for input.

If you're playing at a level where queens get blundered (like at my level) then your opponent is playing at the same level and can do the same. As in life, suck it up and carry on with the disadvantage. Winning a game coming from behind is great. You'll get this same advice from youtubers...don't resign. Every game is about learning and if you quit each time you're behind you skip a lot of learning.

Agree, every game is different, some times you on the money and other days your off. You are going to loose a Queen. Make the best of it. And I agree infinitefrustration, you definitely miss out on learning. Thanks for comment.

I have started to play longer daily games as apposed to the 10 minute version to become a stronger player and play better moves, this strategy has increased my daily rating from 180 to 600. Thanks to all the advice received from the community.
But I have just blundered my queen in a pivotal moment to checkmate my opponent. Now I am down on pieces and "Points". Do I throw the game and resign or do I fight tooth and nail to the end, knowingly the result will still be a loss as I have caused myself to much damage? What would you do?