Why is e4 e5 nf3 nc6 d4 cxd4 nxd4 nxd4 an innacuracy?

3.......Nxd4 is a big mistake. why ? in wide open positions ( as this is, when white pushed 3 d4 and Black too it ) tempi matter a lot. Black is giving up a well centralized knight to get White's Queen to a centralized position. Black has no pieces in play and White will continue his vibrant development -- soon to take over more key squares
#3
It is not that bad, but it centralises the white queen
https://www.chessgames.com/perl/chessgame?gid=1896808
After 1 e4 e5 2 Nf3 Nc6 3 d4 exd4 4 Nxd4 Nxd4 is playable too
https://www.chessgames.com/perl/chessgame?gid=1583023