There is a cheating forum in which you can discuss it: http://www.chess.com/groups/view/cheating-forum
If you suspect someone of cheating, then analyze the game with an engine. If he only makes the best moves in a 50-move game, then it surely gets suspicious. You can report him, with the proof you obtained, at https://support.chess.com/customer/portal/emails/new
See also: https://support.chess.com/customer/portal/articles/1444879-cheaters-cheating-what-you-need-to-know
I'm no grandmaster, obviously, but I swear that a lot of users on this site use chess engines to calculate prospective moves. The thing is... it's hard to tell if they are using a chess engine or not.
I don't want to pretend I know exactly how many people are or aren't cheating, but if people are, what is Chess.com doing to discourage it? My guess is, unless it's blatantly clear and all but obvious, nothing.